Retroelements (REs) comprise about 50% of human genome.
REs contain many regulatory elements and propagate in the genome through the process called
retrotransposition. Retroelements are known to affect neighboring genes expression and can
cause major genomic rearrangements. Many of recent RE integrations are not fixed in
the genome and display considerable polymorphism in human population. RE insertion
polymorphism is often used as a molecular markers for human population genetics
and for medical genetics studies Polymorphic REs offer considerable advantages over other types
of polymorphisms.. Thirst the presence of RE represents identity by descent
since the probability that two different RE were independently integrated in the same
site is neglible. Second RE insertion are stable, since there is now genetic
mechanism for RE excision form the genome. Third RE polymorphisms are easily detected
PRED allows to carry out a search for polymorphic RE insertion with particular features essential for the researcher. These features include RE sequence, location in human genome frequency of insertion in human populations information about nearest genes and their relative position. additionally the database contain information on every single polymorphic retroelement with the reference to the original research paper.
(c) Dr. Ilgar Mamedov (email@example.com), Dr. Anna Amosova (firstname.lastname@example.org), Gleb Fisunov (email@example.com)